Background and Objectives: The lipid metabolism in neonatal preterm is still unknown. Various variables have contributed to this metabolism is related to the respiratory distress syndrome. The aim of this study is to investigate the relationship between serum lipids in the first 12 hours after birth and the respiratory distress syndrome in the preterm neonates was designed and performed.
Materials and Methods: In this descriptive- study, 105 preterm neonates born in Bahonar Karaj hospital (consisted of 35 neonates with RDS and 70 healthy neonates) with gestational age of 27 to 36 weeks and a birth weight of 900 to 3400 grams were examined. Serum triglyceride level, total cholesterol, LDL cholesterol and HDL cholesterol were determined and compared in the mentioned group in the first 12 hours after birth.
Results: No significant correlation was found between serum lipid levels and respiratory distress in the first 12 hours after birth (p-value> 0.05). on the other hand male neonates had less total cholesterol levels (84.71 mg / dl versus 103.86 mg / dl) and LDL (50.263 versus 63.286 mg / dl) in comparison with female neonates (p-value <0.05). There was also a positive correlation between birth weight and LDL (pearson correlation = 0.082, n = 105, p-value = 0.035)
Discussion and Conclusion: pretermneonates had lower Triglyceride concentrations, with very low density lipoprotein. Lipoprotein concentrations increased gradually with gestational age, phospholipids are the essential part of surfactant, in this study there are not significant correlation between serum lipid profile and respiratory distress syndrome. We suggested another study with more sample size for assessing the serum lipid profile and respiratory distress syndrome.